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Search Results for " vitamin k "

24

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36730	Vitamin K1 2,3-epoxide Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide	Others	Others
	Vitamin K1 2,3-epoxide (Phylloquinone oxide) 可被还原为维生素 k,参与维生素k的循环。
T75317	Vitamin K5
	Vitamin K5，一种光敏剂，对细菌和真菌展现出强效抗菌特性。作为PKM2的特异性抑制剂，其对PKM2、PKM1及PKL的IC50值分别为28、191和120 μM。此外，Vitamin K5能诱导colon 26细胞进入凋亡。因其具备的这些性质，Vitamin K5在感染和癌症研究中有应用，并可作为药品、食品和饮料的防腐剂。
T75435	cis-Vitamin K1
	Cis-Vitamin K1 是一种 Vitamin K 的内源性代谢物。
T7636	Phenprocoumon 乙苄香豆,苯丙羟基香豆素
	Phenprocoumon 是一种长效口服抗凝剂和维生素 K 的拮抗剂，是香豆素衍生物。
T5963	Menadione bisulfite sodium Sodium menadione bisulfite,亚硫酸氢钠甲萘醌,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite	Others	Others
	Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) 是可以诱导急性氧化应激的试剂，可用作植物防御活化剂，具有抵抗病菌的作用。
T0360	Chlorindione chlophenadione,Indaliton,氯苯茚二酮,G-25766
	Chlorindione (chlophenadione) 是一种维生素 K1 的拮抗剂，也是一种有效的抗凝剂。
T17025	Tecarfarin ATI-5000,ATI-5923	Others	Others
	Tecarfarin (ATI-5923) 是一种具有口服活性和有效性的维生素 K 环氧化物还原酶 (VKOR) 拮抗剂和大麻素-1受体反向激动剂，具有抗血栓形成活性，可减轻小鼠的腹痛并增加肠道转运。
T4980	Betrixaban maleate	Factor Xa	Metabolism
	Betrixaban maleate 是一种非维生素 K 口服抗凝剂，其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。
T4341	Betrixaban 贝曲西班,PRT054021	Factor Xa	Metabolism
	Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂，IC50=1.5 nM。
T10867	Coumetarol Ph 137,Dicumoxane,库美香豆素
	Coumetarol is an antagonist of vitamin K.
T71543	Difethialone
	Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.
T19708	(S)-Warfarin
	(S)-Warfarin is a more effective enantiomer of Warfarin. It is used as a vitamin K antagonist, with anticoagulant.
T17024	Tecarfarin sodium ATI-5923 sodium	Others	Others
	Tecarfarin sodium is a novel orally active non-competitive vitamin K epoxide reductase antagonist. Tecarfarin sodium has the antithrombotic activity.
T62662	Tioclomarol
	Tioclomarol 是一种香豆素抗凝剂，维生素 K 拮抗剂。
TP1628	Activated Protein C (390-404), human
	Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1].
T36725	6-hydroxy Warfarin
	6-Hydroxywarfarin 是(+)-华法林的代谢物，也一种较弱的维生素 K 拮抗剂。
T12442	Phenindione D5 Rectadione D5,苯茚二酮 D5	Others	Others
	Phenindione D5 is deuterium labeled Phenindione, which functions as a Vitamin K antagonist.
T81205	SARS-CoV-2-IN-66	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-66 (1)，一种维生素K衍生物，作为SARS-CoV-2抑制剂，其在VeroE6/TMPRSS2细胞模型中的EC50值达到70.8 μM。
T81204	SARS-CoV-2-IN-67	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-67 (Compound 16) 是抗SARS-CoV-2的维生素K衍生物，其在VeroE6/TMPRSS2细胞中EC50值为64.8 μM。该化合物能够抑制SARS-CoV-2 RdRp活性。
T37950	2-(Isopentylamino)naphthalene-1,4-dione
	2-(Isopentylamino)naphthalene-1,4-dione is a vitamin K analog.1It inhibits spasms induced by pentylenetetrazole and tonic hindlimb extension induced by maximal electroshock (MES) in mice (ED50s = 349.2 and 108.1 mg/kg, respectively). It also protects mice against seizures in the 6 Hz psychomotor seizure test (ED50s = 152.7 and 263.7 mg/kg at stimulus intensities of 32 and 44 mA, respectively). 1.Li, X., Himes, R.A., Prosser, L.C., et al.Discovery of the first vitamin K analogue as a potential tr...
T22676	Prothrombin (474-477) [Mus musculus]	Others	Others
	Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to
T36203	Menaquinone 9 MK-9,Vitamin K2(45),Menaquinone 9
	Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.
T21693	PPM-18
	PPM-18 (NSC 73233) 是一种有效的抗炎剂，可抑制一氧化氮合酶的表达。PPM-18 是有效的 iNOS 表达抑制剂，可阻断 NF-κB 与启动子的结合。PPM-18 是维生素 K 的类似物，通过 ROS 和 AMPK 信号通路诱导膀胱癌细胞自噬和凋亡。
T36564	(S)-Acenocoumarol
	Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The...

化合物

Vitamin K1 2,3-epoxide

Cat.No: T36730

Synonym: Vitamin K1 epoxide,Phylloquinone oxide,Vitamin K1 2,3-epoxide

Target: Others

Cat.No: T75317

cis-Vitamin K1

Cat.No: T75435

Cat.No: T7636

Synonym: 乙苄香豆,苯丙羟基香豆素

Menadione bisulfite sodium

Cat.No: T5963

Synonym: Sodium menadione bisulfite,亚硫酸氢钠甲萘醌,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite

Target: Others

Cat.No: T0360

Synonym: chlophenadione,Indaliton,氯苯茚二酮,G-25766

Cat.No: T17025

Synonym: ATI-5000,ATI-5923

Target: Others

Betrixaban maleate

Cat.No: T4980

Target: Factor Xa

Cat.No: T4341

Synonym: 贝曲西班,PRT054021

Target: Factor Xa

Cat.No: T10867

Synonym: Ph 137,Dicumoxane,库美香豆素

Cat.No: T71543

Cat.No: T19708

Tecarfarin sodium

Cat.No: T17024

Synonym: ATI-5923 sodium

Target: Others

Cat.No: T62662

Activated Protein C (390-404), human

Cat.No: TP1628

6-hydroxy Warfarin

Cat.No: T36725

Cat.No: T12442

Synonym: Rectadione D5,苯茚二酮 D5

Target: Others

SARS-CoV-2-IN-66

Cat.No: T81205

Target: SARS-CoV

SARS-CoV-2-IN-67

Cat.No: T81204

Target: SARS-CoV

2-(Isopentylamino)naphthalene-1,4-dione

Cat.No: T37950

Prothrombin (474-477) [Mus musculus]

Cat.No: T22676

Target: Others

Cat.No: T36203

Synonym: MK-9,Vitamin K2(45),Menaquinone 9

Cat.No: T21693

(S)-Acenocoumarol

Cat.No: T36564

Cat. No.	Product Name	Target	Signaling Pathways
T19603	Vitamin K Kephton,维生素K,Vitamin K1(20)	Endogenous Metabolite	Metabolism
	Vitamin K (Kephton) 具有凝血作用，对凝血因子、基质-Gla 蛋白和骨钙素很重要。
T2336	Vitamin K2 Menatetrenone,四烯甲萘醌	Endogenous Metabolite	Metabolism
	Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。
T0449	Menadione 维生素K3,Vitamin K3,甲萘醌	Thrombin; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Menadione (Vitamin K3) 是合成的萘醌，能够在体内转化成活性维生素 K2。
T1075	Vitamin K1 Phylloquinone,维生素K1,叶绿醌,Phytomenadione,Phytonadione,Phyllohydroquinone	Others; Endogenous Metabolite	Metabolism; Others
	Vitamin K1 (Phylloquinone)是天然存在的维生素。Vitamin K1是血液凝固，骨和血管代谢所必须的。
T2570	Vitamin K4 维生素K4,维生素 K4,Kapilin,Menadiol Diacetate,acetomenaphthone	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Vitamin K4 (Menadiol Diacetate) 是一种维生素药物，用于治疗因缺乏 VK4 引起的凝血障碍。
T7106	Menaquinone-4 四烯甲萘醌,Vitamin K2,Menaquinone K4	Others; Endogenous Metabolite	Metabolism; Others
	Menaquinone-4 (Vitamin K2) 是维生素 K 的一种，用作止血剂，有潜力用于骨质疏松的研究。
T7050	alpha-Tocopherolquinone 托可醌,Metarene	Antioxidant	oxidation-reduction
	alpha-Tocopherolquinone (Metarene) 会下调线粒体的呼吸活动。在还原为生育酚氢醌后，它还显示出抗氧化活性。在大鼠缺氧期间，已发现它的水平升高。
T0809	Dicoumarol Dicumarol,双羟香豆素,双香豆素	Dehydrogenase; NADPH; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂，它们的IC50值分别为 0.37 和 19.42 μM。
TQ0197	Acenocoumarol 醋硝香豆素,新抗凝
	Acenocoumarol 是一种抗凝血剂，与 Vitamin K 拮抗剂的功能相似。
T14291	Anisindione	Others	Others
	Anisindione 是合成的抗凝血剂，对活性促凝因子II，VII，IX 和X 的形成具有抑制作用。

天然产物

Cat.No: T19603

Synonym: Kephton,维生素K,Vitamin K1(20)

Target: Endogenous Metabolite

Cat.No: T2336

Synonym: Menatetrenone,四烯甲萘醌

Target: Endogenous Metabolite

Cat.No: T0449

Synonym: 维生素K3,Vitamin K3,甲萘醌

Target: Thrombin, Endogenous Metabolite

Cat.No: T1075

Synonym: Phylloquinone,维生素K1,叶绿醌,Phytomenadione,Phytonadione,Phyllohydroquinone

Target: Others, Endogenous Metabolite

Cat.No: T2570

Synonym: 维生素K4,维生素 K4,Kapilin,Menadiol Diacetate,acetomenaphthone

Target: Apoptosis, Endogenous Metabolite

Cat.No: T7106

Synonym: 四烯甲萘醌,Vitamin K2,Menaquinone K4

Target: Others, Endogenous Metabolite

alpha-Tocopherolquinone

Cat.No: T7050

Synonym: 托可醌,Metarene

Target: Antioxidant

Cat.No: T0809

Synonym: Dicumarol,双羟香豆素,双香豆素

Target: Dehydrogenase, NADPH, PDK

Cat.No: TQ0197

Synonym: 醋硝香豆素,新抗凝

Cat.No: T14291

Target: Others

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